To cause someone to lose control of their faculties or behavior due to the consumption of alcohol or drugs. The strong cocktail was enough to intoxicate him after just one drink.
To excite or elate someone to the point of enthusiasm or frenzy. The success of the project seemed to intoxicate the entire team, driving them to work even harder.
To poison or impregnate with a toxic substance. Industrial fumes can intoxicate workers if ventilation is poor.