Extremely sensitive to stimuli or changes in the environment. The supersensitive microphone could pick up even the faintest of whispers.
Easily affected by emotions or feelings, often to an excessive degree. Her supersensitive nature made her prone to tears at the slightest provocation.
In medicine or pharmacology, abnormally or excessively responsive to a drug, hormone, allergen, or other stimulus. After prolonged treatment the dopamine receptors became supersensitive to even small doses of the medication.