To trim or cut away dead or overgrown branches or stems, especially to encourage growth. She decided to prune the rose bushes to help them bloom better in the spring.
To reduce or remove unnecessary or unwanted parts from something. The editor had to prune several paragraphs from the article to fit the word limit.
Of skin: to shrivel or wrinkle after prolonged immersion in water; also, to cause skin to wrinkle in this way. After an hour in the pool, his fingertips had pruned.