To cause someone to feel disgust or aversion due to an excess of something initially pleasant, especially sweetness or sentimentality. The overly sweet dessert began to cloy after just a few bites.
To become distasteful, tiresome, or uninteresting through overabundance or excess. The novelty of the theme park began to cloy after a few visits.
(Archaic) To satiate or fill to the point of disgust; to glut. He was cloyed with luxuries he once thought he desired.