To handle or control a tool, mechanism, etc., typically in a skillful manner. The technician was able to manipulate the controls to fix the machine.
To influence or manage shrewdly or deviously. She knew how to manipulate the conversation to get what she wanted.
To alter or present something in a way that is misleading or not entirely truthful. The company was accused of manipulating the data to make their product appear more effective.
To move, adjust, or massage (a body part) by skilled hand movements, especially for therapeutic purposes. The physiotherapist manipulated the patient's knee to improve its range of motion.