To kill someone unlawfully and with premeditation. The detective was determined to find out who had murdered the victim.
To spoil or ruin something, especially a performance or piece of work, through incompetence or carelessness. He completely murdered the song with his off-key singing.
To defeat decisively or overwhelm completely. Our team was murdered 6–0 in the final.
Informal: To feel a strong desire for (something, especially food or drink) and to be able to consume it eagerly. After the hike, I could murder a cold glass of water.