In a difficult or hopeless situation. After losing his job and missing rent payments, he realized he was completely screwed.
Twisted or turned in a spiral manner. The lid was tightly screwed onto the jar, making it difficult to open.
Intoxicated, especially under the influence of alcohol or drugs. By the time we left the bar, I was completely screwed.
To fasten or tighten something with a screw or screws. He screwed the shelf to the wall to ensure it was secure.
To twist or turn something in a spiral motion. She screwed the cap back onto the bottle tightly.
To cheat or deceive someone. He felt like he was screwed over by the contractor who didn't finish the job.
To have sexual intercourse with someone (informal and often considered vulgar). They were caught screwing in the backseat of the car.
To mess up or make a mistake. I really screwed up the presentation by forgetting my notes.